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IC Protocol (Subject: M/30y/Asian, BMI: 26.0)

Daily

  • NAC (600-1200 mg)
  • Metformin (850 mg)
  • Berberine (300mg)
  • Vitamin C (500-800 mg)
  • Vitamin B1, B6, B12 (NA)
  • Vitamin B3/Niacinamide (300 mg)
  • Ginger root (3000 mg) 
  • Garlic clove (3000 mg)
  • Shallot bulb (3000 mg)
  • Piperine (NA)
  • Silymarin (100 mg)
  • Rutin (300 mg)

Day I (EOD)

  • Zinc (50 mg)
  • Fenofibrate (145 mg micronized; 300mg non-micronized)

Day II (EOD)

  • Zinc (20 mg) + Vitamin D3 (2000 IU)
  • Omega-3 (EPA/DHA) (NA)

PRN use​​

  • Activated Charcoal (1000-1500 mg)
  • Caffeine (NA)(🧠⬆️)
  • Propranolol (20-40 mg)(🧠⬆️)(🫀⬇️)
  • Sulpiride (50 mg)(🧠⬆️)(⚠️)
  • Amitriptyline (10-15 mg)(🌀)(🧠⬇️)(⚠️)
  • Isotretinoin (10 mg)(⚠️)
  • Ashwagandha (NA)
  • Certirizin (10 mg)
  • Alimemazine tartrate (5-10 mg)(🌀)
  • Probiotics (NA)
  • Nicotinic acid (250-500 mg)
  • Aspirin (81-100 mg)(⚠️)
  • Piracetam (800-1600 mg)(🧠⬆️)
  • Carvedilol (6.25 mg)
  • Pramipexole (0.18 mg)
  • Vitamin B6 (40 mg)

PRN combination

  • Propranolol + Piracetam (+ Sulpiride)
  • Caffeine + Piracetam (+ Sulpiride)
  • Carvedilol + Alimemazine tartrate
  • NAC + Silymarin + Rutin + Vit C + B1, B6, B12 + B3
CHANGELOG:

- 20 Jul 2025: [DAILY~] Vitamin C (500 mg) -> Vitamin C (500-800 mg); [DAILY+] Rutin (300 mg)
- 26 Jul 2025: [DAILY+] Piperine (NA)
- 01 Aug 2025: [PRN+] Propranolol (20-40 mg)
- 14 Aug 2025: [PRN+] Piracetam (800-1600 mg)
- 01 Sep 2025: [DAILY+] Carvedilol (6.25 mg) /*Lowers HR; Reduces BP via α1-blockade and vasodilation; Protects heart in CHF; Antioxidant; Promotes mitochondrial biogenesis; Reduces ROS/oxidative stress; Stabilizes cardiac membranes; Neuroprotective anti-inflammatory; Less adverse metabolic impact vs older β-blockers (e.g. Propranolol)*/

- 01 Oct 2025: [PRN -> DAY I] Fenofibrate (145 mg micronized; 300mg non-micronized); [DAY I -> PRN] Isotretinoin (10 mg)
- 30 Nov 2025: [PRN~] Amitriptyline (10-25 mg) -> Amitriptyline (10-15 mg) /* Improves sleep initiation and continuity, via H1 antagonism and 5-HT/NE; Reduces baseline autonomic anxiety; May delay detumescence (peripheral anticholinergic effect); Enhances attentional stability in ADHD with inattentive-type features */
- 08 Mar 2026: [PRN+] Pramipexole (0.18 mg); [PRN+] Vitamin B6 (40 mg); [DAILY -> PRN] Carvedilol (6.25 mg)



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